Hypolipidemic and cardioprotective effects of Taraxacum officinal aqueous extract in obese rats
Obesity is a chronic disease responsible for comorbidity and excess mortality, and is considered an independent risk factor for cardiovascular pathology development. Most cardiovascular disease can be prevented by tackling behavioural risk factors, such as a sedentary lifestyle, unhealthy diet, and...
| Permalink: | http://skupnikatalog.nsk.hr/Record/nsk.NSK01001145233/Details |
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| Matična publikacija: |
Veterinarska stanica (Online) 52 (2021), 4 ; str. 405-412 |
| Glavni autori: | Ikram, Toumi (Author), Ifriqya, Medila, Saoussane, Lifa |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.46419/vs.52.4.6 Hrčak |
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| 024 | 7 | |2 doi |a 10.46419/vs.52.4.6 | |
| 035 | |a (HR-ZaNSK)001145233 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 636.09 |2 2011 | |
| 100 | 1 | |a Ikram, Toumi |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 0 | |a Hypolipidemic and cardioprotective effects of Taraxacum officinal aqueous extract in obese rats |h [Elektronička građa] / |c Toumi Ikram, Medila Ifriqya, Lifa Saoussane. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 42 jed. | ||
| 504 | |a Abstract ; Sažetak. | ||
| 520 | |a Obesity is a chronic disease responsible for comorbidity and excess mortality, and is considered an independent risk factor for cardiovascular pathology development. Most cardiovascular disease can be prevented by tackling behavioural risk factors, such as a sedentary lifestyle, unhealthy diet, and obesity. Taraxacum officinal is a perennial plant belonging to the Asteraceae family, commonly used for these medicinal characteristics. It has diuretic, anti-tumour, antioxidant, anti-inflammatory, hepatoprotective and immunostimulant properties. The aim of this study was to evaluate the lipid-lowering and cardioprotective effect of Taraxacum officinal aqueous extract in Wistar rats on hyperfatty diets. A total of 24 rats weighing 200 ± 6.8 g were divided into three lots: healthy control (HC) receiving a standard diet, obese control (OC) receiving a cafeteria diet without treatment and the third load (TL) receiving a cafeteria diet and treated for 20 days with 200 mg/kg Taraxacum officinal aqueous extract. The results showed that the cafeteria diet induced obesity in rats compared to the control group, characterized by hyperglycaemia (148.75 mg/ dL), hypertriglyceridemia (59 mg/dL) and hypercholesterolemia (160.67 mg/dL) with an increase in total lipids (0.39 g/g of tissue) associated with a state of oxidative stress in the cardiac tissue. Oral administration of the aqueous extract of Taraxacum officinal improved the lipid profile in serum and tissue. The findings showed a drop in blood sugar (1.02 mg/dL), total cholesterol (135 mg/ dL), LDL cholesterol, (67 mg/dL), triglycerides (36 mg/dL), total lipids (1.37g/g of tissue), and lipid peroxidation MDA (0.25 ± 0.02 μmoL/g protein), and an increase in the level of GSH (0.51 nM /mg protein) in treated rats compared to the controls. In conclusion, the results obtained showed the effectiveness of the aqueous extract of Taraxacum officinal against dyslipidemia, obesity, and hyperglycaemia. | ||
| 520 | |a Pretilost je kronična bolest koja je odgovorna za komorbiditet i prekomjernu smrtnost te se smatra neovisnim čimbenikom rizika za razvoj kardiovaskularne patologije. Većinu kardiovaskularnih bolesti moguće je spriječiti rješavanjem faktora rizika ponašanja; sjedilačkog načina života, nezdrave prehrane i pretilosti. Taraxacum officinal je višegodišnja biljka koja pripada obitelji Asteraceae, a obično se rabi zbog svojih medicinskih svojstava. Ima diuretičko, protutumorsko, antioksidativno, protuupalno, hepatoprotektivno i imunostimulacijsko djelovanje. Cilj je ove studije bio procijeniti učinak snižavanja lipida i kardioprotektivni učinak vodenog ekstrakta Taraxacum officinal u štakora soja wistar na vrlo masnoj prehrani. 24 štakora težine 200 ± 6,8 g podijeljeno je u 3 skupine: zdravu kontrolnu (HC) koja je primala standardnu prehranu, pretilu kontrolnu (OC) koja je primala "kantinsku" hranu bez terapije i treću opterećenu skupinu (TL) koja je primala "kantinsku dijetu" i terapiju tijekom 20 dana s 200 mg/kg vodenog ekstrakta Taraxacum officinal. Dobiveni rezultati su pokazali da je "kantinska dijeta" dovela do pretilosti štakora u usporedbi s kontrolnom skupinom okarakteriziranom hiperglikemijom (148,75 mg/dL), hipertrigliceridemijom (59 mg/dL) i hiperkolesterolemijom (160,67 mg/dL) uz povećanje ukupnih lipida (0,39 g/g tkiva) povezano sa stanjem oksidativnog stresa u srčanom tkivu. Oralna primjena vodenog ekstrakta Taraxacum officinal poboljšala je lipidni profil u krvi i tkivu. Nalazi su pokazali pad šećera u krvi (1,02 mg/dL), ukupnog kolesterola (135 mg/dL), LDL kolesterola, (67 mg/ dL), triglicerida (36 mg/dL), ukupnih lipida (1,37 g/g tkiva) i peroksidacije lipida MDA (0,25 ± 0,02 μmoL/g proteina) te povećanje razine GSH (0,51 nM/mg proteina) u štakora koji su primali terapiju u usporedbi s kontrolnim skupinama. Zaključno, dobiveni rezultati dokazali su učinkovitost vodenog ekstrakta Taraxacu. | ||
| 653 | 0 | |a Bolesti srca |a Pretilost |a Dislipidemija |a Oksidativni stres |a Faktori rizika |a Taraxacum officinal | |
| 700 | 1 | |a Ifriqya, Medila |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Saoussane, Lifa |4 aut |9 HR-ZaNSK | |
| 773 | 0 | |t Veterinarska stanica (Online) |x 1849-1170 |g 52 (2021), 4 ; str. 405-412 |w nsk.(HR-ZaNSK)000855872 | |
| 981 | |b Be2021 |b B03/21 | ||
| 998 | |b tino2211 | ||
| 856 | 4 | 0 | |u https://doi.org/10.46419/vs.52.4.6 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/248755 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |