In sickness and in health
Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as “gold stand...
| Permalink: | http://skupnikatalog.nsk.hr/Record/nsk.NSK01001102484/Details |
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| Matična publikacija: |
Biochemia medica (Online) 30 (2020), 2 ; str. 202-214 |
| Glavni autori: | Nikolac, Nora (Author), Unić, Adriana, Miler, Marijana, Pavičić, Tomislav, medicinski biokemičar, Culej, Jelena, Bolanča, Ivan, Herman Mahečić, Davorka, Milevoj Kopčinović, Lara, Vrtarić, Alen |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.11613/BM.2020.020501 Biochemia medica (Online) Hrčak |
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| 001 | NSK01001102484 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20210719105954.0 | ||
| 006 | m d | ||
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| 008 | 210527s2020 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.11613/BM.2020.020501 | |
| 035 | |a (HR-ZaNSK)001102484 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 61 |2 2011 | |
| 080 | 1 | |a 577 |2 2011 | |
| 100 | 1 | |a Nikolac, Nora |4 aut | |
| 245 | 1 | 0 | |a In sickness and in health |h [Elektronička građa] : |b pivotal role of vitamin D / |c Nora Nikolac Gabaj, Adriana Unic, Marijana Miler, Tomislav Pavicic, Jelena Culej, Ivan Bolanca, Davorka Herman Mahecic, Lara Milevoj Kopcinovic, Alen Vrtaric. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 96 jed. | ||
| 504 | |a Summary. | ||
| 520 | |a Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as “gold standard” method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D2 and 25(OH)D3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. Vitamin D is mostly measured in serum or plasma, but new studies are showing importance of measuring vitamin D in pleural effusions, breast milk, urine, synovial fluid and saliva. Besides the main role in calcium homeostasis and bone metabolism, many studies linked vitamin D deficiency with cancer, cardiovascular diseases, diabetes, fertility and many other conditions. However, even though initial observational studies indicated that supplementation with vitamin D might be beneficial in disease development and progression; first results of well-designed randomized controlled prospective studies did not find differences in frequency of cardiovascular events or invasive cancer between patients taking vitamin D supplementation compared to placebo. In the light of these recent findings, validity of excessive vitamin D testing remains an open question. | ||
| 653 | 0 | |a Vitamin D |a Šećerna bolest |a Polimorfizam |a Plodnost |a Preanalitička varijabilnost |a Ekstravaskularne tjelesne tekućine | |
| 700 | 1 | |a Unić, Adriana |4 aut | |
| 700 | 1 | |a Miler, Marijana |4 aut | |
| 700 | 1 | |a Pavičić, Tomislav, |c medicinski biokemičar |4 aut | |
| 700 | 1 | |a Culej, Jelena |4 aut | |
| 700 | 1 | |a Bolanča, Ivan |4 aut | |
| 700 | 1 | |a Herman Mahečić, Davorka |4 aut | |
| 700 | 1 | |a Milevoj Kopčinović, Lara |4 aut | |
| 700 | 1 | |a Vrtarić, Alen |4 aut | |
| 773 | 0 | |t Biochemia medica (Online) |x 1846-7482 |g 30 (2020), 2 ; str. 202-214 |w nsk.(HR-ZaNSK)000655372 | |
| 981 | |b Be2020 |b B03/20 | ||
| 998 | |b dalo2107 | ||
| 856 | 4 | 0 | |u https://doi.org/10.11613/BM.2020.020501 |
| 856 | 4 | 0 | |u https://www.biochemia-medica.com/en/journal/30/2/10.11613/BM.2020.020501 |y Biochemia medica (Online) |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/238902 |y Hrčak |