Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia

Introduction: The aim of the study was to investigate current practice and policies of therapeutic drug monitoring (TDM) service requesting and result reporting in Czechia and Slovakia. Materials and methods: All 149 laboratories that measure plasma drug concentrations were given an online questionn...

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Permalink: http://skupnikatalog.nsk.hr/Record/nsk.NSK01001102477/Details
Matična publikacija: Biochemia medica (Online)
30 (2020), 2 ; str. 272-277
Glavni autori: Šálek, Tomáš (Author), Schneiderka, Petr, Studená, Barbora, Votroubková, Michaela
Vrsta građe: e-članak
Jezik: eng
Predmet:
Online pristup: https://doi.org/10.11613/BM.2020.020706
Biochemia medica (Online)
Hrčak
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024 7 |2 doi  |a 10.11613/BM.2020.020706 
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042 |a croatica 
044 |a ci  |c hr 
080 1 |a 61  |2 2011 
080 1 |a 577  |2 2011 
100 1 |a Šálek, Tomáš  |4 aut 
245 1 0 |a Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia  |h [Elektronička građa] /  |c Tomáš Šálek, Petr Schneiderka, Barbora Studená, Michaela Votroubková. 
300 |b Graf. prikazi. 
504 |a Bibliografija: 20 jed. 
504 |a Summary. 
520 |a Introduction: The aim of the study was to investigate current practice and policies of therapeutic drug monitoring (TDM) service requesting and result reporting in Czechia and Slovakia. Materials and methods: All 149 laboratories that measure plasma drug concentrations were given an online questionnaire during a regular external quality assessment TDM cycle. The questionnaire consisted of 17 questions. The optimal TDM practice was defined as the application of all elements (age, body weight, time of sampling, date of the first administration, time of the last dose administration, the dose, the dosing interval, the route of administration, information on reason of testing, and information on other co–administered drugs) needed for reporting a recommendation for further drug dosing (positive response to question number 16). Results: The response rate was 69%, 103 out of 149 laboratories measuring drug concentrations. Only 12% (12 out of 103 laboratories) of the laboratories implemented all elements needed for optimal TDM practice and reported a recommendation. Both paper and electronic request forms were used by 77 out of 103 (75%) laboratories. A total of 69 out of 103 laboratories (67%) specified the type of sampling tube on their request form. Cystatin C was used for prediction of renal drug elimination by 24% (25 out of 103) of participants. Conclusions: Small number of laboratories implemented all elements needed for optimal TDM practice and report a recommendation on further dosing. Further efforts in education on optimal TDM practice as well as harmonization of service are desirable. 
653 0 |a Lijekovi  |a Farmakokinetika  |a Klinički laboratorij 
653 5 |a Češka  |a Slovačka 
700 1 |a Schneiderka, Petr  |4 aut  |9 HR-ZaNSK 
700 1 |a Studená, Barbora  |4 aut  |9 HR-ZaNSK 
700 1 |a Votroubková, Michaela  |4 aut  |9 HR-ZaNSK 
773 0 |t Biochemia medica (Online)  |x 1846-7482  |g 30 (2020), 2 ; str. 272-277  |w nsk.(HR-ZaNSK)000655372 
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856 4 0 |u https://doi.org/10.11613/BM.2020.020706 
856 4 0 |u https://www.biochemia-medica.com/en/journal/30/2/10.11613/BM.2020.020706  |y Biochemia medica (Online) 
856 4 1 |y Digitalna.nsk.hr 
856 4 0 |u https://hrcak.srce.hr/238909  |y Hrčak