Myasthenia gravis patients with anti-MuSK antibodies

Abstract: In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, there is a variable proportion of patients with antibodies against the muscle-specific kinase (MuSK). MuSK antibodies were found i...

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Permalink: http://skupnikatalog.nsk.hr/Record/nsk.NSK01000737957/Details
Matična publikacija: Collegium antropologicum
33 (2009), 4 ; str. 1151-1154
Glavni autor: Žagar, Marija (-)
Ostali autori: Vranješ, Davorka (-), Šoštarko, Marija, Vogrinc, Željka, Bilić, Ervina, Trbojević-Čepe, Milica
Vrsta građe: Članak
Jezik: eng
Predmet:
Online pristup: Collegium Antropologicum
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100 1 |a Žagar, Marija 
245 1 0 |a Myasthenia gravis patients with anti-MuSK antibodies /  |c Marija Žagar, Davorka Vranješ, Marija Šoštarko, Željka Vogrinc, Ervina Bilić and Milica Trbojević Čepe. 
300 |b Ilustr. 
504 |a Bibliografija: 16 jed 
504 |a Sažetak 
520 8 |a Abstract: In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, there is a variable proportion of patients with antibodies against the muscle-specific kinase (MuSK). MuSK antibodies were found in 8 (29.6%) of our 27 patients with generalized MG without anti-AChR antibodies. All these patients were female. The age at the onset ranged from 22 to 38 years. All patients had ocular and bulbar symptoms, and two patients also had generalized limb weakness. Two patients had pure ocular symptoms for 7 or 8 years before the development of bulbar symptoms. All anti-MuSK positive patients were treated with immunosuppressive drugs, three received plasmapheresis and one patient required mechanical ventilation. Our results are consistent with other literature reports 
653 0 |a Miastenija gravis  |a Specifična mišićna kinaza  |a Acetilkolinski receptori 
700 1 |a Vranješ, Davorka 
700 1 |a Šoštarko, Marija 
700 1 |a Vogrinc, Željka 
700 1 |a Bilić, Ervina 
700 1 |a Trbojević-Čepe, Milica 
773 0 |t Collegium antropologicum  |x 0350-6134  |g 33 (2009), 4 ; str. 1151-1154  |w nsk.(HR-ZaNSK)000000360 
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856 4 2 |u http://hrcak.srce.hr/coll-antropol  |y Collegium Antropologicum