Modern biotechnology of Phellinus baumii

Phellinus baumii is a mushroom used as a folk medicine for a variety of human diseases in several Asian countries. Recently we have reported for the first time about the antidiabetic effect of the crude exopolysaccharides (EPS) produced from submerged mycelial culture of P. baumii in streptozotocin...

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Permalink: http://skupnikatalog.nsk.hr/Record/nsk.NSK01000691345/Details
Matična publikacija: Food technology and biotechnology
45 (2007), 3 ; str. 306-318
Glavni autor: Hwang, Hye Jin (-)
Ostali autori: Kim, Sang Woo (-), Yun, Jong Won
Vrsta građe: Članak
Jezik: eng
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Online pristup: Digitalni arhiv mrežnih publikacija
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245 1 0 |a Modern biotechnology of Phellinus baumii :  |b from fermentation to proteomics /  |c Hye Jin Hwang, Sang Woo Kim and Jong Won Yun. 
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520 |a Phellinus baumii is a mushroom used as a folk medicine for a variety of human diseases in several Asian countries. Recently we have reported for the first time about the antidiabetic effect of the crude exopolysaccharides (EPS) produced from submerged mycelial culture of P. baumii in streptozotocin (STZ)-induced diabetic rats. The diabetic rats study revealed that orally administrated P. baumii EPS lowered the blood glucose levels and stimulated insulin excretion in diabetic rats, and consequently restored the functions of pancreas, liver, and kidney, suggesting that the EPS might be useful for the management of human diabetes mellitus. We undertook proteomic analyses for plasma, pancreas, liver, and kidney of the rats to search for novel biomarkers for monitoring diabetes before and after EPS treatments. In this article, we describe the production of EPS in submerged culture of P. baumii and studies of their hypoglycemic activity. We also explore the issue of proteomic analyses for mining biomarkers of diabetes 
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653 |a Šećerna bolest  |a Fitoterapija  |a Eksperimentalna istraživanja 
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700 1 |a Yun, Jong Won 
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