IL-12 concentrations in the aqueous humor and serum of diabetic retinopathy patients
Background Previous studies suggest that inflammation plays an important part in the pathogenesis of diabetes. Cytokines may have a role in both positive and negative control of immunological reactions. Among many cytokines, interleukin 12 (IL-12) is known to be a strong pro-inflammatory cytokine. M...
| Permalink: | http://skupnikatalog.nsk.hr/Record/ffzg.KOHA-OAI-FFZG:309599/Details |
|---|---|
| Matična publikacija: |
Graefe's archive for clinical and experimental ophthalmology 250 (2012), 6 ; str. 815-821 |
| Glavni autori: | Gverović Antunica, Antonela (-), Karaman, Ksenija (Author), Znaor, Ljubo, Sapunar, Ada, Puzović, Velibor, Buško, Vesna |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Online pristup: |
Elektronička verzija članka |
| LEADER | 03001naa a2200337uu 4500 | ||
|---|---|---|---|
| 005 | 20160815234141.0 | ||
| 008 | 131105s2012 xx eng|d | ||
| 024 | |2 doi |a 10.1007/s00417-011-1905-4 | ||
| 035 | |a (CROSBI)567699 | ||
| 040 | |a HR-ZaFF |b hrv |c HR-ZaFF |e ppiak | ||
| 100 | 1 | |a Gverović Antunica, Antonela | |
| 245 | 1 | 0 | |a IL-12 concentrations in the aqueous humor and serum of diabetic retinopathy patients / |c Gverović Antunica, Antonela ; Karaman, Ksenija ; Znaor, Ljubo ; Sapunar, Ada ; Buško, Vesna ; Puzović, Velibor. |
| 300 | |a 815-821 |f str. | ||
| 363 | |a 250 |b 6 |i 2012 | ||
| 520 | |a Background Previous studies suggest that inflammation plays an important part in the pathogenesis of diabetes. Cytokines may have a role in both positive and negative control of immunological reactions. Among many cytokines, interleukin 12 (IL-12) is known to be a strong pro-inflammatory cytokine. Methods A total of 76 participants were enrolled in this study and classified into four groups: 23 diabetic patients with non-treated retinopathy, 17 diabetic patients with treated retinopathy, 12 diabetic patients without retinopathy, and 24 healthy control patients. Serum and aqueous humor samples were taken for the analysis of IL-12 concentration. Results The aqueous humor IL-12 concentration was significantly elevated in the patients with non-treated diabetic retinopathy (χ2(3, n = 76) = 27.137 ; p < 0.001). No significant differences in IL-12 serum concentrations between the groups were found (F = 0.405, p = 0.750). Correlation analysis of IL-12 concentrations in the serum and aqueous humor showed a linear association between the two variables only in non-diabetic patients (p = 0.003). Conclusions This is the first study to show a significantly higher concentration of pro-inflammatory cytokine IL-12 in the aqueous humor of non-treated diabetic retinopathy patients in comparison with diabetic patients treated for retinopathy, without retinopathy, or with healthy individuals. Because the serum levels of IL-12 did not differ considerably between the studied groups, it is plausible that this is due to its local production and secretion. | ||
| 536 | |a Projekt MZOS |f 130-1301683-1402 | ||
| 546 | |a ENG | ||
| 690 | |a 3.01 | ||
| 690 | |a 3.02 | ||
| 693 | |a Interleukin 12, Cytokine, Diabetic retinopathy, Aqueous humor, Serum |l hrv |2 crosbi | ||
| 693 | |a Interleukin 12, Cytokine, Diabetic retinopathy, Aqueous humor, Serum |l eng |2 crosbi | ||
| 700 | 1 | |a Karaman, Ksenija |4 aut | |
| 700 | 1 | |a Znaor, Ljubo |4 aut | |
| 700 | 1 | |a Sapunar, Ada |4 aut | |
| 700 | 1 | |a Puzović, Velibor |4 aut | |
| 700 | 1 | |9 400 |a Buško, Vesna |4 aut | |
| 773 | 0 | |t Graefe's archive for clinical and experimental ophthalmology |x 0721-832X |g 250 (2012), 6 ; str. 815-821 | |
| 856 | 4 | |u http://www.springerlink.com/content/r17374444054p804/ |y Elektronička verzija članka | |
| 942 | |c CLA |t 1.01 |u 2 |z Znanstveni - clanak | ||
| 962 | |w WOS:000304205900005 |s 2-s2.0-84864314968 | ||
| 999 | |c 309599 |d 309597 | ||